Untargeted lipidomic analysis and network pharmacology for parthenolide treated papillary thyroid carcinoma cells.

ABSTRACT:

Background

With fast rising incidence, papillary thyroid carcinoma (PTC) is the most common head and neck cancer. Parthenolide, isolated from traditional Chinese medicine, inhibits various cancer cells, including PTC cells. The aim was to investigate the lipid profile and lipid changes of PTC cells when treated with parthenolide.

Methods

Comprehensive lipidomic analysis of parthenolide treated PTC cells was conducted using a UHPLC/Q-TOF-MS platform, and the changed lipid profile and specific altered lipid species were explored. Network pharmacology and molecular docking were performed to show the associations among parthenolide, changed lipid species, and potential target genes.

Results

With high stability and reproducibility, a total of 34 lipid classes and 1736 lipi

SUBMITTER: Huang LT 

PROVIDER: S-EPMC10123985 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature