Expression characteristics and their functional role of IGFBP gene family in pan-cancer.

ABSTRACT:

Background

Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in different types of cancer, which we still lack comprehensive and pleiotropic understandings so far.

Methods

Multi-source and multi-dimensional data, extracted from The Cancer Genome Atlas (TCGA), Oncomine, Cancer Cell Line Encyclopedia (CCLE), and the Human Protein Atlas (HPA) was used for bioinformatics analysis by R language. Immunohistochemistry and qRT-PCR were performed to validate the results of the database analysis results. Bibliometrics and literature review were used for summarizing the research progress of IGFBPs in the field of tumor.

Results

The members of IGFBP gene fa

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10124011 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature