Genomic and functional characterization of carbapenem-resistant Klebsiella pneumoniae from hospital wastewater.

ABSTRACT:

Background

The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) attracted extensive attention. Information on CRKP from hospital wastewater (HWW) is limited. The aims of this study were to investigate the genomic characteristics and to evaluate the survivability characteristics of 11 CRKP from HWW in a Chinese teaching hospital in Fujian province.

Results

A total of 11 CRKP from HWW were recovered in this study. All CRKP from HWW were resistant to most antibiotics. Comparative genetic analysis demonstrated that all CRKP isolates were clustered into the three distinct phylogenetic clades and clade 2 and clade 3 were mixtures of samples collected from both HWW and clinical settings. Varieties of resistance genes, virulence genes and plasmid replicon types were de

SUBMITTER: Xie Z 

PROVIDER: S-EPMC10124015 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature