A graph neural network-based interpretable framework reveals a novel DNA fragility-associated chromatin structural unit.

ABSTRACT:

Background

DNA double-strand breaks (DSBs) are among the most deleterious DNA lesions, and they can cause cancer if improperly repaired. Recent chromosome conformation capture techniques, such as Hi-C, have enabled the identification of relationships between the 3D chromatin structure and DSBs, but little is known about how to explain these relationships, especially from global contact maps, or their contributions to DSB formation.

Results

Here, we propose a framework that integrates graph neural network (GNN) to unravel the relationship between 3D chromatin structure and DSBs using an advanced interpretable technique GNNExplainer. We identify a new chromatin structural unit named the DNA fragility-associated chromatin interaction network (FaCIN). FaCIN is a bottleneck-like

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10124043 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature