Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits.

ABSTRACT: The ability to abstract information to guide decisions during navigation across changing environments is essential for adaptation and requires the integrity of the hippocampal-prefrontal circuitry. The hippocampus encodes navigational information in a cognitive map, but it remains unclear how cognitive maps are transformed across hippocampal-prefrontal circuits to support abstraction and generalization. Here, we simultaneously record hippocampal-prefrontal ensembles as rats generalize navigational rules across distinct environments. We find that, whereas hippocampal representational maps maintain specificity of separate environments, prefrontal maps generalize across environments. Furthermore, while both maps are structured within a neural manifold of population activity, they have distinc

SUBMITTER: Tang W 

PROVIDER: S-EPMC10124109 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature