Survival difference between high-risk and low-risk CFTR genotypes after lung transplant.

ABSTRACT:

Background

While cystic fibrosis transmembrane conductance regulator (CFTR) genotypes are associated with clinical outcomes in cystic fibrosis patients, it is unknown if genotype impacts lung transplant outcomes. We sought to compare lung transplant survival and time to bronchiolitis obliterans syndrome (BOS) between high-risk, low-risk, and not yet classified CFTR genotypes.

Methods

We used merged data from the Organ Procurement and Transplantation Network (2005-2017) and United States Cystic Fibrosis Foundation Patient Registry (2005-2016). Cox Proportional Hazards models compared graft failure after lung transplant and time to BOS among high-risk, low-risk, and not yet classified risk CFTR genotype classes.

Results

Among 1,830 cystic fibrosis lung transplant recipi

SUBMITTER: Clausen ES 

PROVIDER: S-EPMC10124119 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature