CD8⁺ T cells contribute to diet-induced memory deficits in aged male rats.

ABSTRACT: We have previously shown that short-term (3-day) high fat diet (HFD) consumption induces a neuroinflammatory response and subsequent impairment of long-term memory in aged, but not young adult, male rats. However, the immune cell phenotypes driving this proinflammatory response are not well understood. Previously, we showed that microglia isolated from young and aged rats fed a HFD express similar levels of priming and proinflammatory transcripts, suggesting that additional factors may drive the exaggerated neuroinflammatory response selectively observed in aged HFD-fed rats. It is established that T cells infiltrate both the young and especially the aged central nervous system (CNS) and contribute to immune surveillance of the parenchyma. Thus, we investigated the modulating role of short

SUBMITTER: Butler MJ 

PROVIDER: S-EPMC10124165 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature