Quantile-specific heritability of monocyte chemoattractant protein-1, and relevance to rs1024611-disease interactions.

ABSTRACT:

Background

Monocyte chemoattractant protein-1 (MCP-1) concentrations are 34% to 47% heritable. Larger -2518 G/A (rs1024611) genotypes differences are reported for: 1) MCP-1 production in stimulated vs. basal cells; and 2) MCP-1 concentrations in diseased (sepsis, brain abscess, hepatitis B virus, Alzheimer's disease, Behcet's disease, and systemic lupus erythematosus) vs. healthy patients. Those results suggest that the -2518 G/A effect size may depend on whether the phenotype is high or low relative to its distribution (quantile-dependent expressivity).

Method

To test whether quantile-dependent expressivity applies more broadly to genetic influences on MCP-1 concentrations, quantile-specific offspring-parent (β_OP) and full-sib regression slopes (β_FS) w

SUBMITTER: Williams PT 

PROVIDER: S-EPMC10124179 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature