Sensitivity and specificity of CRP and symptom screening as tuberculosis screening tools among HIV-positive and negative outpatients at a primary healthcare facility in Lusaka, Zambia: a prospective cross-sectional study.

ABSTRACT:

Objectives

To evaluate the performance of point-of-care C-reactive protein (CRP) as a screening tool for tuberculosis (TB) using a threshold of 10 mg/L in both people living with HIV (PLHIV) and HIV-negative individuals and compare it to symptom screening using a composite reference for bacteriological confirmation of TB.

Methods

Prospective cross-sectional study.

Setting

A primary healthcare facility in Lusaka, Zambia.

Participants

Consecutive adults (≥18 years) presenting for routine outpatient healthcare were enrolled. Of the 816 individuals approached to participate in the study, 804 eligible consenting adults were enrolled into the study, of which 783 were included in the analysis.

Primary outcome measures

Sensitivity, specificity, positive predicti

SUBMITTER: Kagujje M 

PROVIDER: S-EPMC10124229 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature