Cohort study examining associations between ceramide levels and risk of multimorbidity among persons participating in the Mayo Clinic Biobank.

ABSTRACT:

Objective

Ceramides have been associated with several ageing-related conditions but have not been studied as a general biomarker of multimorbidity (MM). Therefore, we determined whether ceramide levels are associated with the rapid development of MM.

Design

Retrospective cohort study.

Setting

Mayo Clinic Biobank.

Participants

1809 persons in the Mayo Clinic Biobank ≥65 years without MM at the time of enrolment, and with ceramide levels assayed from stored plasma.

Primary outcome measure

Persons were followed for a median of 5.7 years through their medical records to identify new diagnoses of 20 chronic conditions. The number of new conditions was divided by the person-years of follow-up to calculate the rate of accumulation of new chronic conditions.

SUBMITTER: St Sauver JL 

PROVIDER: S-EPMC10124265 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature