Vitamin B₁₂ status in infancy and the effect of a vitamin B₁₂ injection in infants with subclinical vitamin B₁₂ deficiency: study protocol for a register-based randomised controlled trial.

ABSTRACT:

Introduction

Vitamin B₁₂ (cobalamin) is crucial for optimal child development and growth, yet deficiency is common worldwide. The aim of this study is twofold; (1) to describe vitamin B₁₂ status and the status of other micronutrients in Norwegian infants, and (2) in a randomised controlled trial (RCT), investigate the effect of vitamin B₁₂ supplementation on neurodevelopment in infants with subclinical vitamin B₁₂ deficiency.

Methods and analysis

Infant blood samples, collected at public healthcare clinics, are analysed for plasma cobalamin levels. Infants with plasma cobalamin <148 pmol/L are immediately treated with hydroxocobalamin and excluded from the RCT. Remaining infants (cobalamin ≥148 pmol/L) are randomly assigned (in a 1

SUBMITTER: Bakken KS 

PROVIDER: S-EPMC10124272 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature