Completion and publication of clinical trials in a cooperative group: a cohort study of trials of the Swiss Group for Clinical Cancer Research (SAKK).

ABSTRACT:

Background

Premature trial discontinuation and non-publication of trial results are still major issues negatively affecting reliable evidence generation.

Objectives

To investigate trial completion and publication rate of cancer trials conducted within the Swiss Group for Clinical Cancer Research (SAKK).

Design

Cohort study of clinical trials.

Setting

Cohort of interventional cancer trials conducted in Switzerland with accrual closure between 1986 and 2021 identified from the SAKK trial management system.

Outcomes

Premature trial discontinuation and publication in peer-reviewed journal.

Results

We included 261 trials; median number of recruited patients was 150.5 (range 1-8028). Most trials (67.0%) were randomised. Overall, 76 of 261 (29.1%) trials

SUBMITTER: Hayoz S 

PROVIDER: S-EPMC10124283 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature