Intratumor childhood vaccine-specific CD4⁺ T-cell recall coordinates antitumor CD8⁺ T cells and eosinophils.

ABSTRACT:

Background

Antitumor mechanisms of CD4⁺ T cells remain crudely defined, and means to effectively harness CD4⁺ T-cell help for cancer immunotherapy are lacking. Pre-existing memory CD4⁺ T cells hold potential to be leveraged for this purpose. Moreover, the role of pre-existing immunity in virotherapy, particularly recombinant poliovirus immunotherapy where childhood polio vaccine specific immunity is ubiquitous, remains unclear. Here we tested the hypothesis that childhood vaccine-specific memory T cells mediate antitumor immunotherapy and contribute to the antitumor efficacy of polio virotherapy.

Methods

The impact of polio immunization on polio virotherapy, and the antitumor effects of polio and tetanus recall were tested in syngeneic murine

SUBMITTER: Brown MC 

PROVIDER: S-EPMC10124325 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature