Non-memory cognitive symptom development in Alzheimer's disease.

ABSTRACT:

Background and purpose

Memory is known to be the most common first symptom in Alzheimer's disease (AD). Assessing non-memory cognitive symptom development in AD is important for understanding disease progression and the potential identification of treatment-responsive subtypes.

Methods

Data from the National Alzheimer's Coordinating Center were examined. Logistic regression models were fitted evaluating the development of judgement, language, visuospatial and attention symptoms at first and second visits to Alzheimer's Disease Centers. Predictors were age and prior symptoms, adjusting for symptom length and sex. The models were then refitted assessing apolipoprotein E ε4 (APOE-ε4) effects.

Results

Each decade reduction in presentation age increased the odds of languag

SUBMITTER: Blenkinsop A 

PROVIDER: S-EPMC10124327 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature