A COVID-19 vaccine candidate based on SARS-CoV-2 spike protein and immune-stimulating complexes.

ABSTRACT: Spike protein from SARS-CoV-2, the etiologic agent of the COVID-19 pandemic disease, constitutes a structural protein that proved to be the main responsible for neutralizing antibody production. Thus, its sequence is highly considered for the design of candidate vaccines. Animal cell culture represents the best option for the production of subunit vaccines based on recombinant proteins since they introduce post-translational modifications that are important to mimic the natural antigenic epitopes. Particularly, the human cell line HEK293T has been explored and used for the production of biotherapeutics since the products derived from them present human-like post-translational modifications that are important for the protein's activity and immunogenicity. The aim of this study was to produc

SUBMITTER: Villarraza J 

PROVIDER: S-EPMC10124706 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature