Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.

ABSTRACT:

Background

Sex differences related to immune responses can influence atopic manifestations in childhood asthma. While genome-wide association studies have investigated a sex-specific genetic architecture of the immune response, gene-by-sex interactions have not been extensively analysed for atopy-related markers including allergy skin tests, IgE and eosinophils in asthmatic children.

Methods

We performed a genome-wide gene-by-sex interaction analysis for atopy-related markers using whole-genome sequencing data based on 889 trios from the Genetic Epidemiology of Asthma in Costa Rica Study (GACRS) and 284 trios from the Childhood Asthma Management Program (CAMP). We also tested the findings in UK Biobank participants with self-reported childhood asthma. Furthermore, downstream

SUBMITTER: Lee S 

PROVIDER: S-EPMC10124713 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature