The Association of Kidney Function with Plasma Amyloid-β Levels and Brain Amyloid Deposition.

ABSTRACT:

Background

Reduced kidney function is related to brain atrophy and higher risk of dementia. It is not known whether kidney impairment is associated with higher levels of circulating amyloid-β and brain amyloid-β deposition, which could contribute to elevated risk of dementia.

Objective

To investigate whether kidney impairment is associated with higher levels of circulating amyloid-β and brain amyloid-β deposition.

Methods

This cross-sectional study was performed within the community-based Atherosclerosis Risk in Communities (ARIC) Study cohort. We used estimated glomerular filtration rate (eGFR) based on serum creatinine and cystatin C levels and urine albumin-to-creatinine ratio (ACR) to assess kidney function. Amyloid positivity was defined as a standardized uptake

SUBMITTER: Sedaghat S 

PROVIDER: S-EPMC10124796 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature