Characterization of the pattern of expression of Gas1 in the kidney during postnatal development in the rat.

ABSTRACT: Growth Arrest-Specific 1 (Gas1) is a pleiotropic protein with different functions, in the adult kidney Gas1 acts as an endogenous inhibitor of cell proliferation but it is also necessary for the maintenance and proliferation of Renal Progenitor Cells (RPC) during early development, thus it fulfills important functions in the adult kidney. However, it is not known whether or not Gas1 is expressed during postnatal development, a critical stage for renal maturation. For this reason, the main objective of this work was to characterize the expression pattern of Gas1 in the different regions of the kidney by immunofluorescence and Western blot analysis during the postnatal development of the rat. We found that Gas1 is present and has a differential expression pattern in the various regions of th

SUBMITTER: Cetina-Palma A 

PROVIDER: S-EPMC10124827 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature