MTSviewer: A database to visualize mitochondrial targeting sequences, cleavage sites, and mutations on protein structures.

ABSTRACT: Mitochondrial dysfunction is implicated in a wide array of human diseases ranging from neurodegenerative disorders to cardiovascular defects. The coordinated localization and import of proteins into mitochondria are essential processes that ensure mitochondrial homeostasis. The localization and import of most mitochondrial proteins are driven by N-terminal mitochondrial targeting sequences (MTS's), which interact with import machinery and are removed by the mitochondrial processing peptidase (MPP). The recent discovery of internal MTS's-those which are distributed throughout a protein and act as import regulators or secondary MPP cleavage sites-has expanded the role of both MTS's and MPP beyond conventional N-terminal regulatory pathways. Still, the global mutational landscape of MTS's rem

SUBMITTER: Bayne AN 

PROVIDER: S-EPMC10124841 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature