Transforming RNA-Seq gene expression to track cancer progression in the multi-stage early to advanced-stage cancer development.

ABSTRACT:

Background

Cancer progression can be tracked by gene expression changes that occur throughout early-stage to advanced-stage cancer development. The accumulated genetic changes can be detected when gene expression levels in advanced-stage are less variable but show high variability in early-stage. Normalizing advanced-stage expression samples with early-stage and clustering of the normalized expression samples can reveal cancers with similar or different progression and provide insight into clinical and phenotypic patterns of patient samples within the same cancer.

Objective

This study aims to investigate cancer progression through RNA-Seq expression profiles across the multi-stage process of cancer development.

Methods

RNA-sequenced gene expression of Diffuse Large B-

SUBMITTER: Livesey M 

PROVIDER: S-EPMC10124877 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature