Impact of age and comorbidities on SARS-CoV-2 vaccine-induced T cell immunity.

ABSTRACT:

Background

Older age and chronic disease are important risk factors for developing severe COVID-19. At population level, vaccine-induced immunity substantially reduces the risk of severe COVID-19 disease and hospitalization. However, the relative impact of humoral and cellular immunity on protection from breakthrough infection and severe disease is not fully understood.

Methods

In a study cohort of 655 primarily older study participants (median of 63 years (IQR: 51-72)), we determined serum levels of Spike IgG antibodies using a Multiantigen Serological Assay and quantified the frequency of SARS-CoV-2 Spike-specific CD4 + and CD8 + T cells using activation induced marker assay. This enabled characterization of suboptimal vaccine-induced cellular immunity. The risk factors of

SUBMITTER: Dietz LL 

PROVIDER: S-EPMC10124939 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature