Uncover DNA damage and repair-related gene signature and risk score model for glioma.

ABSTRACT:

Background

Glioma is a common primary central nervous system tumor with complex pathogenesis. DNA damage and repair (DDR) is widely involved in regulating cell proliferation and tumorigenesis by correcting and repairing DNA damage mechanisms. Recent studies have reported the following properties in cancer cells in glioma, increased DNA damage and reduced DNA repair capacity. However, the relationship between glioma and DDR-related genes was unclear.

Methods

DDR-related risk score model was built. The validity of this model was validated in detail through the Kaplan-Meier survival analysis, tumor mutational burden (TMB) analysis, immune cell infiltration, sensitivity to treatment regimens. Moreover, the model's adaptability was validated in different glioma data cohorts and d

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10124985 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature