Neurofunctional characteristics of executive control in older people with HIV infection: a comparison with Parkinson's disease.

ABSTRACT: Expression of executive dysfunctions is marked by substantial heterogeneity in people living with HIV infection (PLWH) and attributed to neuropathological degradation of frontostriatal circuitry with age and disease. We compared the neurophysiology of executive function in older PLWH and Parkinson's disease (PD), both affecting frontostriatal systems. Thirty-one older PLWH, 35 individuals with PD, and 28 older healthy controls underwent executive task-activated fMRI, neuropsychological testing, and a clinical motor exam. fMRI task conditions distinguished cognitive control operations, invoking a lateral frontoparietal network, and motor control operations, activating a cerebellar-precentral-medial prefrontal network. HIV-specific findings denoted a prominent sensorimotor hypoactivation dur

SUBMITTER: Muller-Oehring EM 

PROVIDER: S-EPMC10124990 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature