HLA Factors versus Non-HLA Factors for Haploidentical Donor Selection.

ABSTRACT: When multiple haploidentical donors are available for transplantation, those of younger generations are generally selected over those of older generations. However, it is unclear who is the optimal donor when selecting candidates from within a generation, such as father versus mother, son versus daughter, or brother versus sister. Although traditionally male donors are favored over female donors, particularly for male recipients, and significant associations of individual HLA mis(matches) on outcomes are being increasingly recognized, the hierarchy of factors for donor selection is indeterminate. To assess whether HLA factors take precedence over non-HLA factors and to isolate the influence of specific characteristics on outcomes, we analyzed 412 patients stratified by donor relationship:

SUBMITTER: Mehta RS 

PROVIDER: S-EPMC10125001 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature