Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics.

ABSTRACT: Many people living with dementia and cognitive impairment have dysfunctional mitochondrial and insulin-glucose metabolism resembling type 2 diabetes mellitus and old age. Evidence from human trials shows that nutritional interventions and anti-diabetic medicines that target nutrient-sensing pathways overcome these deficits in glucose and energy metabolism and can improve cognition and/or reduce symptoms of dementia. The liver is the main organ that mediates the systemic effects of diets and many diabetic medicines; therefore, it is an intermediate target for such dementia interventions. A challenge is the efficacy of these treatments in older age. Solutions include the targeted hepatic delivery of diabetic medicines using nanotechnologies and titration of macronutrients to optimize hepatic

SUBMITTER: Hunt NJ 

PROVIDER: S-EPMC10125004 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature