Protective Role for Smooth Muscle Cell Hepcidin in Abdominal Aortic Aneurysm.

ABSTRACT:

Background

Hepcidin is a liver-derived hormone that controls systemic iron homeostasis, by inhibiting the iron exporter ferroportin in the gut and spleen, respective sites of iron absorption and recycling. Hepcidin is also expressed ectopically in the context of cardiovascular disease. However, the precise role of ectopic hepcidin in underlying pathophysiology is unknown. In patients with abdominal aortic aneurysm (AAA), hepcidin is markedly induced in smooth muscle cells (SMCs) of the aneurysm wall and inversely correlated with the expression of LCN2 (lipocalin-2), a protein implicated in AAA pathology. In addition, plasma hepcidin levels were inversely correlated with aneurysm growth, suggesting hepcidin has a potential disease-modifying role.

Methods

To probe the role of

SUBMITTER: Loick P 

PROVIDER: S-EPMC10125116 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature