Unanticipated Characteristics of a Selective, Potent Neuromedin-U Receptor 2 Agonist.

ABSTRACT: Neuromedin-U (NMU) mediates several physiological functions via its two cognate receptors, NMUR1 and NMUR2. Disentangling the individual roles of each receptor has largely been undertaken through the use of transgenic mice bearing a deletion in one of the two receptors or by testing native molecules (NMU or its truncated version NMU-8) in a tissue-specific manner, in effect, taking advantage of the distinct receptor expression profiles. These strategies have proved quite useful despite the inherent limitations of overlapping receptor roles and potential compensatory influences of germline gene deletion. With these considerations in mind, the availability of potent, selective NMU compounds with appropriate pharmacokinetic profiles would advance the capabilities of investigators undertaking

SUBMITTER: Mehrotra S 

PROVIDER: S-EPMC10125376 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature