Immune Checkpoint Molecule TIGIT Regulates Kidney T Cell Functions and Contributes to AKI.

ABSTRACT:

Significance statement

T cells mediate pathogenic and reparative processes during AKI, but the exact mechanisms regulating kidney T cell functions are unclear. This study identified upregulation of the novel immune checkpoint molecule, TIGIT, on mouse and human kidney T cells after AKI. TIGIT-expressing kidney T cells produced proinflammatory cytokines and had effector (EM) and central memory (CM) phenotypes. TIGIT-deficient mice had protection from both ischemic and nephrotoxic AKI. Single-cell RNA sequencing led to the discovery of possible downstream targets of TIGIT. TIGIT mediates AKI pathophysiology, is a promising novel target for AKI therapy, and is being increasingly studied in human cancer therapy trials.

Background

T cells play pathogenic and reparative roles duri

SUBMITTER: Noel S 

PROVIDER: S-EPMC10125646 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature