Novel Genetic Variants Associated with Chronic Kidney Disease Progression.

ABSTRACT:

Significance statement

eGFR slope has been used as a surrogate outcome for progression of CKD. However, genetic markers associated with eGFR slope among patients with CKD were unknown. We aimed to identify genetic susceptibility loci associated with eGFR slope. A two-phase genome-wide association study identified single nucleotide polymorphisms (SNPs) in TPPP and FAT1-LINC02374 , and 22 of them were used to derive polygenic risk scores that mark the decline of eGFR by disrupting binding of nearby transcription factors. This work is the first to identify the impact of TPPP and FAT1-LINC02374 on CKD progression, providing predictive markers for the decline of eGFR in patients with CKD.

Background

The incidence of CKD is associated with genetic factors. However, genetic markers

SUBMITTER: Han M 

PROVIDER: S-EPMC10125649 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature