Multiomics Analyses Reveal Sex Differences in Mouse Renal Proximal Subsegments.

ABSTRACT:

Significance statement

Sex-dependent differences in kidney function are recognized but the underlying molecular mechanisms are largely unexplored. Advances in genomics and proteomic technologies now allow extensive characterization of differences between the same cell types of males and females. Multiomics integrating RNA-seq, ATAC-seq, and proteomics data to investigate differences in gene expression, chromatin accessibility, and protein expression in proximal tubules of male and female mice identified many sex-biased genes and proteins associated with kidney functions, including metabolic and transport processes. Sex differences may also arise from variations of the interaction between transcription factors and accessible chromatin regions. A comprehensive web resource is provide

SUBMITTER: Chen L 

PROVIDER: S-EPMC10125651 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature