Reactive Oxygen Species-Triggered Hydrogen Sulfide Release and Cancer-Selective Antiproliferative Effect of Anethole Dithiolethione-Containing Polymeric Micelles.

ABSTRACT: Hydrogen sulfide (H₂ S) is a gaseous signaling molecule in the human body and has attracted attention in cancer therapy due to its regulatory roles in cancer cell proliferation and migration. Accumulating evidence suggests that continuous delivery of H₂ S to cancer cells for extended periods of time suppresses cancer progression. However, one major challenge in therapeutic applications of H₂ S is its controlled delivery. To solve this problem, polymeric micelles are developed containing H₂ S donating-anethole dithiolethione (ADT) groups, with H₂ S release profiles optimal for suppressing cancer cell proliferation. The micelles release H₂ S upon oxidation by reactive oxygens species (ROS) that are present inside the cells. Th

SUBMITTER: van der Vlies AJ 

PROVIDER: S-EPMC10125727 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature