Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy.

ABSTRACT:

Objective

Epilepsy may cause chronic cognitive impairment by disturbing sleep plasticity. Sleep spindles play a crucial role in sleep maintenance and brain plasticity. This study explored the relationship between cognition and spindle characteristics in adult epilepsy.

Methods

Participants underwent one-night sleep electroencephalogram recording and neuropsychological tests on the same day. Spindle characteristics during N2 sleep were extracted using a learning-based system for sleep staging and an automated spindle detection algorithm. We investigated the difference between cognitive subgroups in spindle characteristics. Multiple linear regressions were applied to analyze associations between cognition and spindle characteristics.

Results

Compared with no/mild cognit

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10125769 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature