Enhanced putamen functional connectivity underlies altered risky decision-making in age-related cognitive decline.

ABSTRACT: Risky decision-making is critical to survival and development, which has been compromised in elderly populations. However, the neural substrates of altered financial risk-taking behavior in aging are still under-investigated. Here we examined the intrinsic putamen network in modulating risk-taking behaviors of Balloon Analogue Risk Task in healthy young and older adults using resting-state fMRI. Compared with the young group, the elderly group showed significantly different task performance. Based on the task performance, older adults were further subdivided into two subgroups, showing young-like and over-conservative risk behaviors, regardless of cognitive decline. Compared with young adults, the intrinsic pattern of putamen connectivity was significantly different in over-conservative ol

SUBMITTER: Ren P 

PROVIDER: S-EPMC10126002 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature