Influence of image reconstruction on quantitative cardiac ¹⁵O-water positron emission tomography.

ABSTRACT:

Background

The impact on quantitative ¹⁵O-water PET/CT of a wide range of different reconstruction settings, including regularized reconstruction by block-sequential regularized expectation maximization (BSREM), was investigated.

Methods

Twenty clinical stress scans from patients referred for assessment of myocardial ischemia were included. Patients underwent a 4-min dynamic stress PET scan with ¹⁵O-water on a digital PET/CT scanner. Twenty-two reconstructions were generated from each scan and a clinical reconstruction was used as reference. Varied parameters were number of iterations, filter, exclusion of time-of-flight and point-spread function, and regularization parameter with BSREM. Analyses were performed in aQuant utilizing two different methods

SUBMITTER: Nordstrom J 

PROVIDER: S-EPMC10126040 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature