Dataset Information

A computed tomography study investigating the effects of botulinum toxin injections prior to complex abdominal wall reconstruction.

ABSTRACT:

Objective

To explore how intramuscular injection of botulinum toxin A (BTA) affects the lateral abdominal wall (LAW) musculature, abdominal- and hernia dimensions, and muscle structure on computed tomography (CT) in patients scheduled for complex abdominal wall reconstruction (CAWR).

Methods

Retrospective analysis of prospectively registered patients who received bilateral intramuscular BTA injections into all three muscles of the LAW. Only patients for which a CT was available before and 3-6 weeks after BTA treatment prior to surgery were analyzed.

Results

Fifty-two patients were analyzed. Median hernia width in all patients decreased with 0.4 cm (IQR - 2.1;0.6) (p = 0.023). Median intra-abdominal transverse diameter increased with 0.9 cm (IQR - 0.2;3.3) (p = 0.001) and the intra-abdominal anterior-posterior diameter decreased with 0.5 cm (IQR - 1.3;0.5) (p = 0.017), making the abdomen more oval. Median LAW muscle length increased with 0.9 cm (IQR 0.0;2.4) per side (p < 0.001), muscle thickness decreased with 0.5 cm (IQR - 0.8;- 0.2) (- 25.0%) per side (p < 0.001), and muscle mass decreased with 3.9 cm² (IQR - 6.4;-1.5) (- 15.8%) per side (p < 0.001). Median HU of the psoas muscles (density) increased with 4.8 HU (IQR 0.4;9.7) (10.3%) per side (p < 0.001). Effects of BTA were more pronounced in patients with a loss of domain (LoD) ≥ 20%.

Conclusions

The main effect of BTA injections is elongation and thinning of the LAW muscles, more than a decrease in hernia width. Concomitantly, the abdomen becomes more oval. An increase of psoas muscles density is seen, associated with offloading of the LAW muscles. Patients with large LoD have a proportionally higher effect of BTA.

SUBMITTER: Claessen JJM

PROVIDER: S-EPMC10126041 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

A computed tomography study investigating the effects of botulinum toxin injections prior to complex abdominal wall reconstruction.

Claessen J J M JJM Timmer A S AS Hemke R R Atema J J JJ Hompes R R Boermeester M A MA Rutten M V H MVH

Hernia : the journal of hernias and abdominal wall surgery 20221014 2

<h4>Objective</h4>To explore how intramuscular injection of botulinum toxin A (BTA) affects the lateral abdominal wall (LAW) musculature, abdominal- and hernia dimensions, and muscle structure on computed tomography (CT) in patients scheduled for complex abdominal wall reconstruction (CAWR).<h4>Methods</h4>Retrospective analysis of prospectively registered patients who received bilateral intramuscular BTA injections into all three muscles of the LAW. Only patients for which a CT was available be ...[more]

PMID: 36239824

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Dataset Information

A computed tomography study investigating the effects of botulinum toxin injections prior to complex abdominal wall reconstruction.

Objective

Methods

Results

Conclusions

Publications

A computed tomography study investigating the effects of botulinum toxin injections prior to complex abdominal wall reconstruction.

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