Characterization of the m⁶A regulator-mediated methylation modification patterns in oral squamous cell carcinoma.

ABSTRACT: N⁶-methyladenosine (m⁶A) is a form of posttranscriptional modification that plays important roles in cancer including oral squamous cell carcinoma (OSCC). Most studies to date have focused on a limited number of regulators and oncogenic pathways, thus failing to provide comprehensive insight into the dynamic effects of m⁶A modification. In addition, the role of m⁶A modification in shaping immune cell infiltration in OSCC has yet to be clarified. This study was designed to assess m⁶A modification dynamics in OSCC and to understand how such modifications influence clinical immunotherapeutic treatment outcomes. m⁶A modification patterns linked with 23 m⁶A regulators were analyzed in 437 OSCC patients from TCGA and GE

SUBMITTER: Pan L 

PROVIDER: S-EPMC10126108 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature