Site-specific ⁶⁸Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models.

ABSTRACT:

Background

CD70-CD27 is a costimulatory ligand-receptor pair in the tumor necrosis factor receptor family. With only limited expression in normal tissues, CD70 is constitutively expressed in a variety of solid tumors and hematologic malignancies, facilitating immunosuppression through CD27 signaling in the tumor microenvironment by enhanced survival of regulatory T cells, induction of T cell apoptosis, and T cell exhaustion. Consequently, CD70 is an increasingly recognized target for developing antibody-based therapies, but its expression patterns vary among different tumor types in spatial distribution, magnitude of expression and percentage of positive cells. In that regard, individual confirmation of CD70 expression at screening and during treatment could enhance the successful

SUBMITTER: Dewulf J 

PROVIDER: S-EPMC10126183 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature