Non-spike and spike-specific memory T cell responses after the third dose of inactivated COVID-19 vaccine.

ABSTRACT:

Background

During the COVID-19 epidemic, vaccination has become the most safe and effective way to prevent severe illness and death. Inactivated vaccines are the most widely used type of COVID-19 vaccines in the world. In contrast to spike-based mRNA/protein COVID-19 vaccines, inactivated vaccines generate antibodies and T cell responses against both spike and non-spike antigens. However, the knowledge of inactivated vaccines in inducing non-spike-specific T cell response is very limited.

Methods

In this study, eighteen healthcare volunteers received a homogenous booster (third) dose of the CoronaVac vaccine at least 6 months after the second dose. CD4⁺ and CD8⁺ T cell responses against a peptide pool from wild-type (WT) non-spike proteins and spike pep

SUBMITTER: Huang R 

PROVIDER: S-EPMC10126277 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature