Hydroxyanthracene derivates citotoxicity: A differential evaluation between single molecule and whole plant extract.

ABSTRACT: Hydroxyanthracene derivates (HADs) are a group of natural or synthetic compounds with a wide range of biological activities (for instance, anti-inflammatory, antibacterial, and antiarthritic). In addition, because of their properties for helping the normal bowel function, HADs are widely used in constipation as pharmacological drugs and nutritional supplements. Nevertheless, during the past years, a safety usage of HAD products has been under consideration because some studies reported that HADs are not lacking toxicity (i.e., genotoxic and carcinogenic activity). Thus, the first objective of this study is to shed light on the large variability in composition of botanical food supplements containing HAD by a systematic analysis of the qualitative and quantitative composition of a cohort of

SUBMITTER: Tinti L 

PROVIDER: S-EPMC10126332 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature