Efficacy and safety of selegiline for the treatment of Parkinson's disease: A systematic review and meta-analysis.

ABSTRACT:

Background

Drug efficacy generally varies with different durations. There is no systematic review analyzing the effect of selegiline for Parkinson's disease (PD) on different treatment duration. This study aims to analyze how the efficacy and safety of selegiline changes for PD over time.

Methods

PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure and Wanfang Database were systematically retrieved for randomized controlled trials (RCTs) and observational studies of selegiline for PD. The search period was from inception to January 18th, 2022. The efficacy outcomes were measured by the mean change from baseline in the total and sub Unified Parkinson's Disease Rating Scale (UPDRS), Hamilton Depression Rating Scale (HAMD) and Webster Rating Scale (WRS)

SUBMITTER: Wang K 

PROVIDER: S-EPMC10126343 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature