Diagnostic value of combination of biomarkers for malignant pleural mesothelioma: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Early-stage accurate diagnosis of malignant pleural mesothelioma (MPM) has always been a formidable challenge. DNA and protein as biomarkers for the diagnosis of MPM have received considerable attention, and yet the outcomes are inconsistent.

Methods

In this study, a systematic search employing PubMed, EMBASE, and Cochrane Library to identify relevant studies from the first day of databases to October 2021. Moreover, we adopt the QUADAS-2 to evaluate the quality of eligible studies and Stata 15.0 and Review Manager 5.4 software programs to perform the meta-analysis. Additionally, bioinformatics analysis was performed at GEPIA for the purpose of exploring relationship between related genes and the survival time of MPM patients.

Results

We included 15 studi

SUBMITTER: Zhu M 

PROVIDER: S-EPMC10126368 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature