Altered serum metabolome associated with vascular calcification developed from CKD and the critical pathways.

ABSTRACT:

Introduction

Vascular calcification (VC) is more likely to be detected in the chronic kidney disease (CKD) population. The mechanism of VC development from CKD is different from that for simple VC and has always been a major research area. The aim of this study was to detect alterations in the metabolome during development of VC in CKD and to identify the critical metabolic pathways and metabolites involved in its pathogenesis.

Methods

Rats in the model group were given an adenine gavage combined with a high-phosphorus diet to imitate VC in CKD. The aorta calcium content was measured and used to divide the model group into a VC group and non-vascular calcification group (non-VC group). The control group was fed a normal rat diet and given a saline gavage. Ultra-high-performa

SUBMITTER: Tan R 

PROVIDER: S-EPMC10126378 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature