Systematic characterization of Ustilago maydis sirtuins shows Sir2 as a modulator of pathogenic gene expression.

ABSTRACT: Phytopathogenic fungi must adapt to the different environmental conditions found during infection and avoid the immune response of the plant. For these adaptations, fungi must tightly control gene expression, allowing sequential changes in transcriptional programs. In addition to transcription factors, chromatin modification is used by eukaryotic cells as a different layer of transcriptional control. Specifically, the acetylation of histones is one of the chromatin modifications with a strong impact on gene expression. Hyperacetylated regions usually correlate with high transcription and hypoacetylated areas with low transcription. Thus, histone deacetylases (HDACs) commonly act as repressors of transcription. One member of the family of HDACs is represented by sirtuins, which are deacetyl

SUBMITTER: Navarrete B 

PROVIDER: S-EPMC10126416 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature