Incidence and type of adverse events in patients taking vonoprazan: A systematic review and meta-analysis.

ABSTRACT:

Background

Vonoprazan, a novel acid-suppressive drug, is non-inferior to proton pump inhibitors (PPIs) for the management of gastric acid-related diseases. However, the safety of vonoprazan has not been systematically evaluated yet.

Objectives

To elucidate the incidence and type of adverse events (AEs) in patients taking vonoprazan.

Design

Systematic review and meta-analysis.

Data sources and methods

PubMed, EMBASE, and Cochrane Library databases were searched for all studies reporting the safety of vonoprazan. The incidences of any AEs, drug-related AEs, serious AEs, AEs leading to drug discontinuation, and common AEs were pooled. Odds ratios (ORs) were calculated to compare the incidence of AEs between patients taking vonoprazan and PPIs.

Results

Seven

SUBMITTER: Xu W 

PROVIDER: S-EPMC10126681 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature