SH3BP1 Regulates Melanoma Progression Through Race1/Wace2 Signaling Pathway.

ABSTRACT:

Background

SH3-domain binding protein-1 (SH3BP1), which specifically inactivates Rac1 and its target protein Wave2, has been shown to be an important regulator of cancer metastasis. However, the effects of SH3BP1 in melanoma progression remain unclear. The current study aimed to explore the function of SH3BP1 in melanoma and its possible molecular mechanism.

Methods

TCGA database was used to analyze the expression of SH3BP1 in melanoma. Then, reverse transcription-quantitative polymerase chain reaction was performed to detect the expression of SH3BP1 in melanoma tissues and cells. Next, genes related to SH3BP1 were analyzed by LinkedOmics database, and protein interactions were analyzed by STRING database. These genes were further subjected to Gene Ontology and Kyoto Encyclo

SUBMITTER: Sun T 

PROVIDER: S-EPMC10126683 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature