Correlation of NNMT and DKK1 Protein Expression With Clinicopathological Characteristics and Prognosis of Breast Cancer.

ABSTRACT:

Background

Nicotinamide N-methyltransferase (NNMT) and Dickkopf-1 (DKK1) play an important role in the development of breast cancer, and the purpose of this study was designed to examine the clinical and prognostic significance of NNMT and DKK1 in breast cancer.

Methods

The GEPIA2 database was used to evaluate the expression and survival of NNMT mRNA and DKK1 mRNA of breast cancer. Then an immunohistochemical study was carried out on 374 cases of breast tissue to identify the protein expression and significance of NNMT and DKK1. Next, the prognostic significance of DKK1 in breast cancer was explored by COX and Kaplan-Meier models.

Results

Protein NNMT expression was correlated with lymph node metastasis and histological grade (P < .05) while protein DKK1 expres

SUBMITTER: Liang T 

PROVIDER: S-EPMC10126688 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature