The severity of corneal nerve loss differentiates motor subtypes in patients with Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is a heterogeneous movement disorder with patients manifesting with either tremor-dominant (TD) or postural instability and gait disturbance (PIGD) motor subtypes. Small nerve fiber damage occurs in patients with PD and may predict motor progression, but it is not known whether it differs between patients with different motor subtypes.

Objective

The aim of this study was to explore whether there was an association between the extent of corneal nerve loss and different motor subtypes.

Methods

Patients with PD classified as TD, PIGD, or mixed subtype underwent detailed clinical and neurological evaluation and corneal confocal microscopy (CCM). Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), and corneal nerve f

SUBMITTER: Che NN 

PROVIDER: S-EPMC10126700 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature