Gemini surfactant-like peptide-based nanocages with β-sheet-enhanced stability and encapsulation efficiency of hydrophobic anticancer drugs.

ABSTRACT: Peptide-based scaffolds have been widely applied to drug delivery because of their ease and high yields of synthesis, well-defined structure, biocompatibility, diversity, tunability of properties, and molecular recognition abilities. However, the stability of peptide-based nanostructures highly depends on the intermolecular assembling manner, e.g., α-helix based coiled coils, β-sheet. Inspired by the robust protein fibril structures in amyloidosis, herein we constructed a β-sheet-forming gemini surfactant-like peptide to self-assemble into nanocages with the help of molecular dynamics simulation. As expected, the experimental results showed that nanocages can be formed with the inner diameter of up to ∼400 nm, which were robust enough even under both transmission electron microscopy

SUBMITTER: Gao F 

PROVIDER: S-EPMC10126818 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature