Prediction of thrombosis in polycythemia vera: Development and validation of a multiple factor-based prognostic score system.

ABSTRACT:

Background

Thrombosis is an important cause of death in patients with polycythemia vera (PV). The conventional stratification of thrombosis may ignore some potential risk factors.

Objectives

This study aimed to develop and validate a multiple factor-based prediction model of thrombosis for the 2016 World Health Organization-dened PV.

Methods

Clinical and next-generation sequencing data from 2 cohorts of patients with PV were analyzed. Multivariable Cox regression analyses were conducted for the identification of thrombotic risk factors and model development.

Results

The study involved 372 patients in the training cohort and another 195 patients in the external validation cohort. Multivariable analyses indicated that age ≥60 years (hazard ratio [HR] 2.56, 95% CI

SUBMITTER: Gu W 

PROVIDER: S-EPMC10126922 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature