Cerebrospinal fluid penetration of fosfomycin in patients with ventriculitis: an observational study.

ABSTRACT:

Background

For treatment of ventriculitis, vancomycin and meropenem are frequently used as empiric treatment but cerebrospinal fluid (CSF) penetration is highly variable and may result in subtherapeutic concentrations. Fosfomycin has been suggested for combination antibiotic therapy, but data are sparse, so far. Therefore, we studied CSF penetration of fosfomycin in ventriculitis.

Methods

Adult patients receiving a continuous infusion of fosfomycin (1 g/h) for the treatment of ventriculitis were included. Routine therapeutic drug monitoring (TDM) of fosfomycin in serum and CSF was performed with subsequent dose adaptions. Demographic and routine laboratory data including serum and CSF concentrations for fosfomycin were collected. Antibiotic CSF penetration ratio as well as b

SUBMITTER: Konig C 

PROVIDER: S-EPMC10127017 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature